Effects of Oxaliplatin, Carboplatin, and Cisplatin Across Treatment on High-Frequency Objective and Subjective Auditory Measures in Adults Platinum chemotherapies are often ototoxic, initially affecting the basal end of the cochlea. Thus, monitoring high-frequency auditory function is advised to reveal early damage. Objective measures of high-frequency auditory function are repeatable over time, but the sensitivity of these measures for monitoring patients receiving platinum derivatives have not been established. ... Article
Article  |   June 16, 2017
Effects of Oxaliplatin, Carboplatin, and Cisplatin Across Treatment on High-Frequency Objective and Subjective Auditory Measures in Adults
Author Affiliations & Notes
  • Laura Dreisbach
    School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, CA
  • Melissa Ho
    School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, CA
  • Erin Reid
    School of Medicine, University of California, San Diego, La Jolla, CA
  • Jonathan Siegel
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL
  • Disclosures
    Disclosures ×
  • Financial: The Knowles Hearing Center at Northwestern University supported this work.
    Financial: The Knowles Hearing Center at Northwestern University supported this work.×
  • Nonfinancial: Laura Dreisbach has no relevant nonfinancial interests to disclose. Melissa Ho has no relevant nonfinancial interests to disclose. Erin Reid has no relevant nonfinancial interests to disclose. Jonathan Siegel has no relevant nonfinancial interests to disclose.
    Nonfinancial: Laura Dreisbach has no relevant nonfinancial interests to disclose. Melissa Ho has no relevant nonfinancial interests to disclose. Erin Reid has no relevant nonfinancial interests to disclose. Jonathan Siegel has no relevant nonfinancial interests to disclose.×
Article Information
Hearing Disorders / Part 1
Article   |   June 16, 2017
Effects of Oxaliplatin, Carboplatin, and Cisplatin Across Treatment on High-Frequency Objective and Subjective Auditory Measures in Adults
Perspectives of the ASHA Special Interest Groups, June 2017, Vol. 2, 17-38. doi:10.1044/persp2.SIG6.17
History: Received February 7, 2017 , Revised April 6, 2017 , Accepted April 6, 2017
Perspectives of the ASHA Special Interest Groups, June 2017, Vol. 2, 17-38. doi:10.1044/persp2.SIG6.17
History: Received February 7, 2017; Revised April 6, 2017; Accepted April 6, 2017

Platinum chemotherapies are often ototoxic, initially affecting the basal end of the cochlea. Thus, monitoring high-frequency auditory function is advised to reveal early damage. Objective measures of high-frequency auditory function are repeatable over time, but the sensitivity of these measures for monitoring patients receiving platinum derivatives have not been established. We monitored 13 patients across oxaliplatin, carboplatin, or cisplatin treatment using the highest frequencies with responses for each individual. Behavioral thresholds and distortion product otoacoustic emission (DPOAE) gross frequency (f2=16–2 kHz) and concentrated frequency (1/48 octave steps at the highest frequency with a present DPOAE) sweeps were monitored. DPOAE results indicated changes during treatment within individuals using absolute change criteria, as well as statistically significant differences across trial when analyzing group data. Changes varied depending on the drug administered. Behavioral thresholds changed less often than DPOAE measures and when changes were noted, they initially occurred at the highest frequencies monitored. Often, DPOAE changes occurred at frequencies which conventional equipment could not monitor (>8 kHz). Additionally, some changes were characterized by DPOAE level enhancements at conventional frequencies (<8 kHz), while levels at higher frequencies were reduced. Overall, objective high-frequency measures were sensitive to auditory changes in adults undergoing platinum chemotherapy treatment.

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