Acute Ischemic Lesions Associated With Impairments in Expression and Recognition of Affective Prosody Purpose We aimed to: (a) review existing data on the neural basis of affective prosody; (b) test the hypothesis that there are double dissociations in impairments of expression and recognition of affective prosody; and (c) identify areas of infarct associated with impaired expression and/or recognition of affective prosody after acute ... Article
Article  |   July 12, 2016
Acute Ischemic Lesions Associated With Impairments in Expression and Recognition of Affective Prosody
Author Affiliations & Notes
  • Amy E. Wright
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD
  • Cameron Davis
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD
  • Yessenia Gomez
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD
  • Joseph Posner
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD
  • Christopher Rorden
    Center for Aphasia Research and Rehabilitation, University of South Carolina, Columbia, SC
  • Argye E. Hillis
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD
    Department of Cognitive Science, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD
  • Donna C. Tippett
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD
    Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
  • Disclosures
    Disclosures ×
  • Financial: The research reported in this paper was supported by the National Institutes of Health (National Institute of Neurological Disorders and Stroke) through award R01 NS04769 and P41 EB015909. The content is solely the responsibility of the authors and does not necessarily represent the views the National Institutes of Health.
    Financial: The research reported in this paper was supported by the National Institutes of Health (National Institute of Neurological Disorders and Stroke) through award R01 NS04769 and P41 EB015909. The content is solely the responsibility of the authors and does not necessarily represent the views the National Institutes of Health.×
  • Nonfinancial: The authors have no relevant nonfinancial information to disclose.
    Nonfinancial: The authors have no relevant nonfinancial information to disclose.×
Article Information
Special Populations / Speech, Voice & Prosody / Part 2
Article   |   July 12, 2016
Acute Ischemic Lesions Associated With Impairments in Expression and Recognition of Affective Prosody
Perspectives of the ASHA Special Interest Groups, July 2016, Vol. 1, 82-95. doi:10.1044/persp1.SIG2.82
History: Received February 4, 2016 , Revised May 3, 2016 , Accepted May 11, 2016
Perspectives of the ASHA Special Interest Groups, July 2016, Vol. 1, 82-95. doi:10.1044/persp1.SIG2.82
History: Received February 4, 2016; Revised May 3, 2016; Accepted May 11, 2016

Purpose We aimed to: (a) review existing data on the neural basis of affective prosody; (b) test the hypothesis that there are double dissociations in impairments of expression and recognition of affective prosody; and (c) identify areas of infarct associated with impaired expression and/or recognition of affective prosody after acute right hemisphere (RH) ischemic stroke.

Methods Participants were tested on recognition of emotional prosody in content-neutral sentences. Expression was evaluated by measuring variability in fundamental frequency. Voxel-based symptom mapping was used to identify areas associated with severity of expressive deficits.

Results We found that 9/23 patients had expressive prosody impairments; 5/9 of these patients also had impaired recognition of affective prosody; 2/9 had selective deficits in expressive prosody; recognition was not tested in 2/9. Another 6/23 patients had selective impairment in recognition of affective prosody. Severity of expressive deficits was associated with lesions in right temporal pole; patients with temporal pole lesions had deficits in expression and recognition.

Conclusions Expression and recognition of prosody can be selectively impaired. Damage to right anterior temporal pole is associated with impairment of both, indicating a role of this structure in a mechanism shared by expression and production of affective prosody.

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